Side Effects of Hydrocortisone probutate

Hydrocortisone probutate is a prescription medication used to treat a variety of skin conditions. It belongs to a class of drugs called corticosteroids. Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many functions, including reducing inflammation.


What is Hydrocortisone probutate used for?

Hydrocortisone probutate is a topical steroid that is used to treat inflammation and itching associated with certain skin conditions such as eczema, psoriasis, and other inflammatory skin conditions. It is available in a cream, ointment, or solution.


Hydrocortisone probutate brand names

Here is the list of brand names that are used for hydrocortisone probutate: 


United States

  • Pandel



  • Barriere-Hc
  • Cortate
  • Cort-Eze
  • Cortoderm Mild Ointment
  • Cortoderm Regular Ointment
  • Emo-Cort
  • Emo-Cort Scalp Solution
  • Hydrocortisone Cream
  • Novo-Hydrocort
  • Novo-Hydrocort Cream
  • Prevex Hc
  • Sarna Hc


Which body parts should be avoided when using Hydrocortisone probutate?

Only the skin should be used for this medication. Keep it out of your eyes. It should not be applied to skin that has been burned, scraped, or cut. Rinse it off with water as soon as possible if it does get on these locations.


If your doctor hasn’t instructed you to, avoid using this medication for longer than two weeks on your face, groin, or underarms.


Only skin diseases that your doctor is treating with this medication should be used. If you think there might be a skin infection present, specifically, consult your doctor before using it for any other conditions. This medicine should not be used to treat certain kinds of skin infections or conditions, including severe burns.


How long does Hydrocortisone probutate stay in your system?

The amount of time that Hydrocortisone probutate stays in your system is dependent on the duration of use of the medicine. Some research suggests that suppression of cortisol levels is still apparent 96 hours after topical use of corticosteroid creams, which implies that Hydrocortisone probutate can stay in your system for long periods of time, possibly for up to a few weeks. Hydrocortisone probutate is not recommended for long term use. More research is required about the half-life of Hydrocortisone probutate and how long it stays in your system. 


According to the NHS, for people who use Hydrocortisone probutate for extended periods of time (more than 12 months in adults), a withdrawal reaction may occur which can include:

  • redness or changes in skin color (hyperpigmentation)
  • burning, stinging, itching or peeling of the skin, or oozing, open sores


What are the side effects of Hydrocortisone probutate?

Check with your doctor immediately if any of the following side effects occur:

  • Backache
  • blistering, burning, crusting, dryness, flaking, irritation, itching, scaling, severe redness, soreness, stinging, or swelling of the skin
  • burning, itching, and pain in the hairy areas, pus at the root of the hair
  • burning and itching of the skin with pinhead-sized red blisters
  • darkening of the skin
  • blurred vision
  • diarrhea
  • dizziness
  • dry mouth
  • facial hair growth in females
  • fainting
  • fractures
  • fruit-like breath odor
  • full or round face, neck, or trunk
  • increased hunger or thirst
  • increase urination
  • increased hair growth on the forehead, back, arms, and legs
  • irritability
  • lightening of the normal skin color
  • lightening of treated areas of the dark skin
  • loss of appetite
  • loss of sexual desire or ability
  • menstrual irregularities
  • mental depression
  • muscle wasting
  • nausea
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • stomach pain
  • sweating
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
  • thinning, weakness, or wasting away of the skin
  • trouble breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting


Why does my skin burn when I apply Hydrocortisone probutate to my skin?

If your skin burns after applying Hydrocortisone probutate to your skin, you may have an allergic reaction to the steroid cream and your skin cannot tolerate it. Hydrocortisone probutate also contains cetostearyl alcohol which may cause acute allergic reactions.


How do I taper down from using Hydrocortisone probutate?

To taper down from using hydrocortisone probutate many doctors advise adjusting to using a weaker steroid cream over an extended period of time. This is commonly known as climbing down the topical steroid ladder.


Which steroid creams are weaker than Hydrocortisone probutate?

According to the Topical Steroid Potency Strength Chart, hydrocortisone probutate is a medium-strength topical steroid. Below is the list of the topical steroids weaker than hydrocortisone probutate: 

  • Hydrocortisone valerate 0.2%
  • Prednicarbate
  • Alclometasone dipropionate
  • Desonide 0.05%
  • Fluocinolone acetonide
  • Hydrocortisone 0.5% – 2.5%
  • Hydrocortisone


Which steroid creams are stronger than Hydrocortisone probutate?

Here are the topical steroids stronger than hydrocortisone probutate: 

  • Augmented betamethasone dipropionate
  • Clobetasol propionate
  • Desoximetasone
  • Augmented diflorasone diacetate
  • Diflorasone diacetate
  • Fluocinonide
  • Flurandrenolide 4 mcg/cm2
  • Halobetasol propionate
  • Amcinonide
  • Betamethasone dipropionate
  • Halcinonide
  • Mometasone furoate
  • Amcinonide
  • Fluticasone propionate
  • Triamcinolone acetonide 0.5%
  • Betamethasone valerate
  • Fluocinolone acetonide
  • Flurandrenolide
  • Hydrocortisone valerate
  • Triamcinolone acetonide
  • Betamethasone valerate 0.1%
  • Clocortolone pivalate
  • Fluticasone propionate
  • Hydrocortisone butyrate


What happens when you use Hydrocortisone probutate too often?

If you use Hydrocortisone probutate too frequently or for an extended period of time, tolerance or tachyphylaxis to that potency level of steroid cream may develop. Hydrocortisone probutate is not recommended for extended use which may result in some of the common side effects listed above. Consult with your doctor if you have concerns. 


Does Hydrocortisone probutate cause topical steroid withdrawal?

More research is required to understand the complexity of Topical Steroid Withdrawal and its specific connection to Hydrocortisone probutate. Hydrocortisone probutate is a highly potent corticosteroid commonly used for skin conditions and the side effects of discontinuing the use of this topical steroid medicine is yet to be studied.


Throughout online groups and communities, there are serious concerns, accounts, discussions and images about corticosteroid creams (not just Hydrocortisone probutate) causing Topical Steroid Withdrawal. The accounts and experiences of the Topical Steroid Withdrawal community continues to grow and has gathered media wide attention for the aesthetic physical severity of many suffering. 


Topical Steroid Withdrawal is an iatrogenic health phenomena that requires more research and studies. The International Topical Steroid Awareness Network (ITSAN) is currently building a patient registry to begin preliminary studies.


Is there treatment for Topical Steroid Withdrawal?

At TSW Assist, we are identifying crowd sourced recommendations of products, solutions, routines, treatments, therapies that can help manage the inflammation and symptoms during the withdrawal period from topical steroids. Currently, there is no medical cure for Topical Steroid Withdrawal. 


Through the community, we are finding treatments to manage the symptoms of TSW, through the tracking of the efficacy of specific products and solutions.


Treatment for Managing Topical Steroid Withdrawal


Disclaimer: The information on this website is not medical advice. There is no known medical cure for topical steroid withdrawal, but there are solutions to manage the symptoms and inflammation. It should not be mistaken that all usage of steroid creams will cause topical steroid withdrawal. Corticosteroid creams are the most common medical treatment for eczema worldwide. More clinical research is required to understand the cause of Topical Steroid Withdrawal within an individual.